Immunotherapy: Open Access
Open Access

Abstract

A Brief Note on Cytokine-Induced Killer Cells

Jong Wook*

Cytokine-Induced killer (CIK) cells are raising growing interest in cellular antitumor therapy, as they can be easily expanded with a straightforward and inexpensive protocol, and are safe requiring only GMP-grade cytokines to obtain very high amounts of cytotoxic cells. CIK cells do not need antigen-specific stimuli to be activated and proliferate, as they recognize and destroy tumor cells in an HLA-independent fashion through the engagement of NKG2D. In several preclinical studies and clinical trials, CIK cells showed reduced allo reactivity compared to conventional T cells, even when challenged across HLA-barriers.

Published Date: 2021-05-27; Received Date: 2021-05-06