Andrology-Open Access
Open Access

Abstract

A Mini-Review of Sildenafil's Paradoxical Roles in Oncology

Bin Zhao, Meiqi Lu, Zhijin Li, Caobin Ma, Yongquan Lu, Yan Wang, Anran Sun, Zheng Wan*

Sildenafil, a renowned Phosphodiesterase type 5 (PDE5) inhibitor, has a well-established role in managing erectile dysfunction by promoting Nitric Oxide (NO)-mediated relaxation of the corpus cavernosum. Beyond its urological applications, emerging research underscores its anti-tumoral efficacy in diverse cancers. However, concerns arise from its potential pro-tumoral role, with several studies indicating an association between Sildenafil use and increased melanoma risk. Although causality remains debated, the drug's dual oncological potential necessitates a discerning evaluation of its therapeutic application. This mini-review seeks to amalgamate information about the therapeutic and anti-tumor consequences of sildenafil in oncology, aiming to furnish guidance for its more prudent use.

Published Date: 2025-01-17; Received Date: 2023-10-10