Immunotherapy: Open Access
Open Access

Abstract

A Novel Research Area of PCDH-PC in Inhibition of Prostate Cancer Cells Invasion and Metastasis through Epithelial: Mesenchymal Transition

Xuezhen Yang*, Xu Jiang, Xueping Ma, Tomonori Habuchi and Yinglu Guo

Objective: To evaluate the effects of Protocadherin-PC (PCDH-PC) gene expression on Epithelial Mesenchymal Transition (EMT) in prostate cancer cells.

Methods: Western blot analysis, morphological analysis, and in vitro wound closure assay were used to assess the effects of inhibition of PCDH-PC expression on EMT in the androgen-independent prostate cancer cell lines DU- 145 and PC-3.

Results: Inhibition of PCDH-PC expression promoted Mesenchymal Epithelial Transition (MET) of DU-145 and PC-3 cells, which changed the cytomorphology to resemble that of the androgen-dependent prostate adenocarcinoma cells LNCaP, and slowed down the growth rate.

Conclusions: Inhibition of PCDH-PC expression reduced the invasiveness of androgen-independent prostate cancer cells.

Published Date: 2020-10-29; Received Date: 2020-09-29