Journal of Proteomics & Bioinformatics
Open Access

Abstract

A Python Based Hydrophilicity Plot to Assess the Exposed and Buried Regions of a Protein

P. Pandarinath, A. Appa Rao and G. Lavanya Devi

Predicting the antigenic regions of a protein is of prime importance in assessing the states of a polypeptide chain as exposed or buried regions. This can be achieved by calculating and plotting the hydrophilicity of a protein using values of Hoop-Woods scale. Hence, in this paper, we report a hydrophilicity plot of Hoop-Woods scale amino acid sequence of a protein on its x-axis, and degree of hydrophobicity or hydrophilicity on its y-axis using python language as architecture by utilizing various functional attributes such as scipy, matplot and numpy modules. A case study has been reported using siallidase-4 enzyme. The program code can be available on request.