Journal of Physical Chemistry & Biophysics
Open Access

Abstract

A Simple and Efficient Multicomponent Synthesis of Novel Pyrazole, N-Aminopyridine and Pyrazolo[3,4-b]Pyridine Derivatives in Water

Mervat Mohammed Abdelkhalik*, Abdulaziz Alnajjar, Solwan Maher Ibrahim, Mohammed Abdelmonem Raslan and Kamal Usef Sadek

The three-component reaction of enaminones, benzaldehyde and hydrazine-HCl or four-component reaction of enaminones, benzaldehyde, hydrazine-HCl and ethyl cyanoacetate in water in the presence of catalytic amount of ammonium acetate has been devised as a straightforward, sustainable approach for the synthesis of 1-H-pyrazole, N-aminopyridine and pyrazol[3,4-b]pyridine derivatives. The key benefit of this approach is simple experimental procedure associated with cost effective and environmentally friendly techniques.

Published Date: 2024-02-01; Received Date: 2024-01-02