Gynecology & Obstetrics
Open Access

Abstract

Analysis of Risk Factors and Prognosis for Ovarian Metastasis in Patients with Endometrial Carcinoma

Qun Zhao and Yumei Wu

Objective: To investigate the risk factors and prognosis for ovarian metastasis in patients with endometrial carcinoma.
Methods of study: Seven hundred sixty-four cases of endometrial carcinoma treated in Beijing Obstetrics and Gynecology Hospital (BOGH) during the period between September, 1970 and August, 2011 were retrospectively analyzed. All the cases had complete surgical and pathological records.
Results: Among 764 cases of endometrial carcinoma analyzed, 23 (3.01%) cases had ovarian metastasis. Univariate analyses found that the depth of muscular invasion, peritoneal lavage cytology, histological grading, cervical migration, parametrial metastasis, fallopian tube metastasis and lymph node metastasis were significantly different between two groups with (n=23) or without (n=741) ovarian metastasis. Multivariate Logistic regression analysis revealed that factors predictive of ovarian metastasis included peritoneal lavage cytology and the depth of muscular invasion. Endometrial carcinoma patients with ovarian metastasis had poorer five-year survival rate and higher recurrent rate than those without ovarian metastasis.
Conclusion: Parametrial metastasis, positive tumor cells in peritoneal lavage and deep muscular invasion are independent risk factors for ovarian metastasis of endometrial carcinoma. Endometrial carcinoma patients with ovarian metastasis are more poorly prognostic.