Chemotherapy: Open Access
Open Access

Abstract

Body Weight and Hematological Parameter Change in Advanced Breast Cancer Following Adjuvant Chemotherapy

Mohamad Luthfi, Indra Wijaya and Heri Fadjari

Background: Body weight change commonly occurs in breast cancer patients who receive adjuvantchemotherapy. However, there was lack of information associated with weight loss and hematological parameterchange. The purpose of this study was to evaluate the body weight and hematological parameter change followingadjuvant chemotherapy in advanced breast cancer.

Methods: This prospective observational study included 50 advanced breast cancer (Stage IIIB and stage IV)subject who were receiving adjuvant chemotherapy with Doxorubicin and Cyclophosphamide regiment. Body weight,Body Mass Index (BMI), Body Surface Area (BSA) and hematological parameter were measured before the onset ofchemotherapy, then after first and second cycles of chemotherapy.

Results: Based on the study results, the subject body weight was decrease after first and second cycleschemotherapy from 60.06 ± 11.16 kg to 61.33 ± 16.61 and 58.69 ± 10.41 kg (p<0.05), respectively. The BMI wasalso decrease from 25.66 ± 4.10 kg/m2 to 25.33 ± 4.12 and 25.05 ± 4.12 kg/m2 (p<0.05), respectively. Body surfacearea also decrease from 1.58 ± 0.16 m2 to 1.58 ± 0.16 and 1.57 ± 0.15 m2 (p<0.05), respectively.Hemoglobin and Total Lymphocyte Count (TLC) level significantly decrease after first and second cycles ofchemotherapy. Hemoglobin level decrease from 12.04 ± 1.35 g/dL to 11.29 ± 1.32 and 10.97 ± 1.47 g/dL (p<0.05),and TLC decrease from 2235.61 ± 701.02/mm3 to 1916.42 ± 670.77 and 1894.82 ± 712.13/mm3 (p<0.05),respectively.There was no significant decrease in leukocyte and Absolute Neutrophil Count (ANC) level after first and secondcycles of chemotherapy (p=0.06 and p=0.56).Conclusion: Body weight, BMI and BSA significantly decrease after first and second cycles of chemotherapy.

Hemoglobin and Total Lymphocyte Count (TLC) level significantly decrease after first and second cycles ofchemotherapy. Hemoglobin level decrease from 12.04 ± 1.35 g/dL to 11.29 ± 1.32 and 10.97 ± 1.47 g/dL (p<0.05),and TLC decrease from 2235.61 ± 701.02/mm3 to 1916.42 ± 670.77 and 1894.82 ± 712.13/mm3 (p<0.05),respectively.

There was no significant decrease in leukocyte and Absolute Neutrophil Count (ANC) level after first and secondcycles of chemotherapy (p=0.06 and p=0.56).

Conclusion: Body weight, BMI and BSA significantly decrease after first and second cycles of chemotherapy.Hemoglobin and TLC level also significantly decrease but there is no significant decrease in leukocyte and ANClevel. Appropriate nutritional management interventions with follow-up programs are needed.