HIV: Current Research
Open Access

Abstract

CD4 Profile and Relationship with Bacterial Isolates from the Blood of HIV-1 Patients attending Art Clinic at a Tertiary Healthcare Institution in Southwest, Nigeria

Tolulope O Oladosu, Tinuola T Adebolu and Muftau K Oladunmoye

The types of bacterial species present in the blood of HIV-1 positive individuals attending the Antiretroviral Therapy (ART) clinic of a Federal Medical Centre in Southwest Nigeria was evaluated in relation to the patients’ CD4 profile. Blood samples were collected from the antecubital regions of five hundred (500) confirmed HIV Patients attending the ART clinic. The collected samples were subjected to standard microbiological techniques for the isolation and identification of bacterial species present in the sample while their CD4 populations were determined using standard technique. The bacterial isolates with the highest frequency of occurrence in the group of patients with severe immunosuppression (≤ 200 cells/mm3) was Salmonella typhimurium while Enterobacter aerogenes, Streptococcus pneumoniae and Shigella dysenteriae dominated the population of bacterial isolates from the blood of HIV patients with CD4 counts of 201-300, 300 - 400 and 300 – 500 cells/mm3 respectively. Sociodemographic and socioeconomic parameters such as age, occupation and nutrition alongside ART were observed to affect the CD4 profile of the patients.