Journal of Cell Science & Therapy
Open Access

Abstract

CDKs: Much More Than Just the Control of Cell Cycle Progression

Felicia Hanzu and Xavier Escoté

Lee and colleagues have shown that CDK4 plays a central role in glucose homeostasis. Insulin activates cyclin D1–CDK4, leading to a decrease in circulating glucose as a consequence of the down-regulation of main genes involved in liver gluconeogenesis.