International Journal of Physical Medicine & Rehabilitation
Open Access

Abstract

Controversial Aspects of Static Respiratory Compliance and D-Dimer in COVID-19 Associated ARDS

Chiara Mega*, Tommaso Tonetti, Alessio Dell’Olio and Marco Vito Ranieri

Clinical outcomes in COVID-19 associated acute respiratory distress syndrome may be influenced by respiratory system mechanics, CT scan findings, oxygenation variables and biomarkers. Low respiratory system compliance and high plasmatic D-dimer were associated to higher mortality rate in a subgroup of COVID-19 patients. Our purpose is to review the impact of respiratory compliance and plasmatic D-dimer in COVID-19 associated acute respiratory distress syndrome according to recent literature. Increased D-dimer concentration in COVID-19 patients is a strong predictor of worse outcome while static respiratory compliance is not. Combined evaluation of both enhances the prediction of mortality in COVID-19 related ARDS.

Published Date: 2021-07-22; Received Date: 2021-07-01