Angiology: Open Access
Open Access

Abstract

Correlation between D-dimer and Cancer-associated Thrombosis: A Systematic Review and Meta-analysis

Jiayuan Li, Lei Zhang, Yuan Wang, Zhanli Guo, Xiaoting Hu, Ruoning Li, Ying Dong and Jianjun Sun*

This article evaluates the impact of D-dimer on Venous Thromboembolism (VTE) in cancer patients through a systematic review of the literature. The study searched the PubMed, Embase, and Cochrane databases from 2009 to 2023 and conducted a meta-analysis following PRISMA guidelines. The results indicated that D-dimer significantly increased the risk of VTE (HR: 1.29; 95% Confidence Interval (CI): 1.11-1.47, I² = 34.8%). A total of 23,658 patients were included in the analysis of 32 eligible studies, demonstrating moderate heterogeneity among the studies (I²=34.8%). This review not only elucidates the relationship between d-dimer and VTE risk but also underscores the potential clinical utility of this molecular marker. Despite certain methodological limitations, the findings provide a substantial body of scientific evidence to inform future medical decisions and prevention strategies.

Aim: A systematic review of the literature assessed the influence of d-dimer levels on the development of venous thrombosis (VTE) in patients with cancer.

Methods and results: Between 2009 and 2023, the articles were searched for in PubMed, Embase, and the Cochrane Library, including all relevant studies, and the search strategy has been implemented. This meta-analysis was conducted in accordance with PRISMA, Preferred Reporting Items for Systematic Literature Review and Meta-Analysis. The Odds Ratio (OR), Hazard Ratio (HR), and 95% CI were then calculated and pooled by means of a random effect model. The statistical diversity was evaluated by using I². A comprehensive review was carried out of 32 eligible studies for the pooling of data in our trial. The total number of patients was 23658 and the characteristics. D-dimer significantly increased the risk of VTE [HR: 1.29; 95% CI, 1.11-1.47, I²=34.8%]. Between studies, there was a moderate degree of heterogeneity (I²=34.8%).

Conclusion: D-dimer is an efficient predictor of VTE risk, which should be considered as a classification and promising tool to assess the risk of thromboembolic events in patients with cancer.

Published Date: 2024-12-23; Received Date: 2024-11-22