Endocrinology & Metabolic Syndrome
Open Access

Abstract

Curcumin Derivatives in Experimental Diabetes

Rezq AM

Curcumin, from the rhizomes of Curcuma longa, is characterized by its anti-diabetic properties, among other healing properties primarily because it is a relatively safe and inexpensive. The application of curcum derivatives for the treatment of experimental diabetes and its complications has paced long ways. Curcumin and its derivatives affect most of aspects of diabetes; including plasma insulin levels, hyperglycemia, hyperlipidemia, and pancreatic islet regeneration with enhanced insulin synthesis and secretion. Such derivatives were developed to overcome the poor bioavailability of natural curcumin. Promising derivatives with conserved natural functional groups of curcumin and some suitable carrier systems need to be extended to clinical trials.