Journal of Clinical Microbiology and Antimicrobials
Open Access

Abstract

DNA Binding and Antimicrobial Studies on Bivalent Transition Metal Complexes with 2-Acetylpyridine Isonicotinoylhydrazone

K Hussain Reddy* and YB Nagaman

Bivalent transition metal [Co(II), Ni(II), Cu(II) and Zn(II)] complexes with 2-acetylpyridine isonicotinoyl hydrazone(APINH, LH) have been prepared and analyzed based on mass spectra, molar conductivity, FT-IR and UVVis spectral data. The ML2complexes are found to be non-electrolytes. From FT-IR data it is evident that the APINH acts as uni-negative tridentate ligand. Electronic spectral data confers octahedral structure for the complexes. The copper complex is also studied using ESR spectroscopy. The Spin Hamiltonian, orbital reduction and bonding parameters are determined for the complex. DNA binding properties of the complexes uncovered by using UVVisible spectrophotometry. Of all the compounds, the nickel complex binds more strongly than either. The metal complexes are screened for their antibacterial activity against pathogenic bacterial strains viz. Gram–ve bacteria (Escherichia coli, Klebsiella pneumonia) and Gram +ve bacteria (Bacillus cereus, Staphylococcus aureus). The copper complex shows more activity than other complexes under investigation.

Published Date: 2021-04-23; Received Date: 2021-04-02