Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Ashok Kumar and Mohammad Nadeem Khan*
This prospective observational study was conducted over one year in the Orthopedic Department at Raichur Institute of Medical Sciences to evaluate the demographic distribution, treatment patterns, drug utilization and Adverse Drug Reactions (ADRs) in patients with Osteoarthritis (OA) and Rheumatoid Arthritis (RA). The study included 215 adult patients aged 18-80 years, diagnosed with OA or RA, excluding those with severe comorbidities. A pre-designed Case Record Form (CRF) was used to collect data, including demographic details, suspected drugs, ADRs and concomitant medications. Diagnoses were made using the American College of Rheumatology (ACR) guidelines for RA and radiological criteria for OA. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) were the most commonly prescribed medication for both OA (44.45%) and RA (26.58%), with analgesics and Disease-Modifying Antirheumatic Drugs (DMARDs) being widely used in RA patients. The study revealed a higher prevalence of OA in males (56.07%) and RA in females (67.07%), with both conditions most common in the 51-65 age groups. Oral administration was the predominant route of drug delivery in both groups and monotherapy was more frequent in OA (79.23%), while combination therapy was prevalent in RA (28.88%). ADR, including gastric discomfort and abdominal pain, were more common in RA patients (12.19% and 3.65%) than in those with OA (1.86% and 0.93%). The study highlighted the need for personalized treatment strategies to optimize therapeutic outcomes and minimize ADRs, emphasizing continuous monitoring and adjustment of therapeutic regimens based on patient demographics and clinical responses.
Published Date: 2024-11-28; Received Date: 2024-10-29