Chemotherapy: Open Access
Open Access

Abstract

Effect of 2-Nitropropane on Chemical Neurotransmission, Spontaneous and Evoked, in the Sartorius Muscle of the Frog

Sergio Lucio Becerra-Torres and Luis Castillo-Hernández

n this project we studied the effect of 2-nitropropane in spontaneous and evoked chemical neurotransmission, using as a model the frog neuromuscular junction, in vitro. The experiments were carried out in the sciatic nerve- sartorius muscle preparation. Our results show that neurotransmission was inhibited, manifesting as a decrease in the amplitude and instantaneous frequency of miniature end-plate potentials and the reduction of end-plate potentials amplitude of the neuromuscular junction, evoked by nerve stimulation. Because 2-nitropropane showed inhibitory effects at peripheral level, we recommend that in work environments where there is exposure to organic solvents, neurological clinical examinations must be performed to detect abnormalities or neurological damage the earlie