Journal of Clinical Trials
Open Access

Abstract

Effects of a glucagon-like peptide-1 (GLP-1) booster on blood glucose, HbA1c, insulin, and GLP-1 levels, body weight and body fat in overweight adult men and women

Xuesheng Han* and Gregory L. Snow

Glucagon-Like Peptide-1 (GLP-1, a human hormone) drugs have unwanted side effects and limitations. One alternative is to utilize medicinal plants to boost endogenous secretion of GLP-1. GLP-1 Booster (GB) contains green tea leaf extract, Gardeniae fructus extract, Turmeric root extract, Black pepper extract, Fenugreek seed extract, Ginseng root extract and White kidney bean extract. A total of ten overweight adult humans completed a 12-week study. In 12 weeks participants saw significant reductions in fasting blood glucose (from 89.8 to 82 mg/dL, p <0.001), insulin (from 43.2 to 36.1 pmol/L, p <0.001), HbA1c (from 5.33% to 5.13%, p <0.01), total cholesterol (166.4 vs 141.0 mg/dL, p <0.001), Systolic Pressure (p <0.001), Diastolic Pressure (p <0.05), Body Weight (171.29 vs 163.39 lbs, p <0.001), Body Fat Mass (42.26 vs 34.11lbs, p<0.001), Body Fat Percentage (25.24% vs 21.24%, p<0.001), Body Fat Index (BFI) (6.81 vs 5.53 kg/m2, p<0.001), Body Mass Index (BMI) (26.95 vs 25.69 kg/ m2, p<0.001), Waist Hip Ratio (WHR) (0.875 vs 0.857, p < 0.05). Fasting GLP-1 level improved from 6.49 pmol/L to 7.27 pmol/L (p <0.001). Participants reported 42.2% decrease in Feeling of Hunger (p <0.001), 80.5% increase in Feeling of Fullness (p <0.001), 48.6% decrease in Desire to Eat (p <0.001) and 43.1% decrease in Eat How Much Food (p < 0.001). GB can be effective in improving endogenous GLP-1 levels, reducing blood glucose, suppressing cravings and losing body fat for overweight adults.

Published Date: 2025-03-21; Received Date: 2025-02-14