Journal of Alcoholism & Drug Dependence
Open Access

Abstract

Effects of Energy Drink on Glomerular Parameters and its Conservation by Vitamin D3

Syeda Sara Bano* and Hussain Ali Bokhari

Objective: Use of energy drinks is increasing now a days and red bull is common brand used by youth that causes nephrotoxicity. Therefore present study was conducted to observe conservative effect of vitamin D3 on renal histomorphological changes induced by EDs.

Study design: Laboratory based experimental study.

Place and duration of study: The research was carried out from 1st august to 30th September 2019 at National institute of health (NIH), Islamabad.

Material and Method: Total thirty adult male albino rats were divided into 3 groups, each group containing ten rats. Group A was control group while rats in group B received 3.57ml/kg body weight red bull that corresponds to one can of ED (250ml) in humans orally for 8 weeks. Rats in group C received 3.57ml/kg body weight red bull along with 5000 IU/kg body weight vitamin D3 orally for 8 weeks. After completion of 8 weeks rats were sacrificed their right kidneys were removed and Slides were prepared using PAS stain. Readings were taken through image j software and results were analyzed by SPSS.

Results: The results demonstrated that in group B use of red bull for 8 weeks resulted in decrease in radius and diameter of glomerular along with widening of bowman capsule space. In group C radius of glomerulus, diameter of glomerulus and bowman capsule space was near to control group. This showed that vitamin D3 conserved glomerulus histology significantly in group C and prevented renal damage (P≤0.05).

Conclusion: In conclusion, vitamin D3 is having noticeable conservative effect in preventing renal histomorphological changes caused energy drink.

Published Date: 2021-10-26; Received Date: 2021-10-04