Journal of Nutrition & Food Sciences
Open Access

Abstract

Effects of Nutritional Status on Peripheral Immune Cells in Patients with Nonsmall Cell Lung Cancer

Fang He, Dongliang Yang, Xiankui Zha, Ping Wang and Liang Xuan*

Background: The nutritional status affects gene expression in peripheral T lymphocytes; nevertheless, the link between nutritional status and immunity of cancer patients is unclear. The aim of the research was to evaluate the connection with nutritional parameters and the frequencies of T cells subsets on peripheral blood in non-small cell lung cancer (NSCLC) patients.

Methods: We enrolled 170 NSCLC patients and 53 healthy volunteers who were age and gender matched. The frequencies of circulating CD3+, CD4+, CD8+, naïve CD4+, memory CD4+, naïve CD8+, memory CD8+, and regulatory T lymphocytes were assessed by the way of flow cytometry. Nutritional parameters including albumin, globulin, albumin to globulin ratio (AGR), total protein (TP), pre-albumin (PA), body mass index (BMI), and prognostic nutritional index (PNI), were also evaluated.

Results: Low globulin levels and high AGR were associated with high frequencies of naïve CD8+ T lymphocytes (P=0.039 and P=0.018). Obese (BMI ≥ 25) Compare with the non-obese (BMI<25) patients, the percentages of CD8+ T lymphocytes in NSCLC patients had decreased (P=0.026). Between in other nutritional parameters and the frequency of circulating lymphocyte subsets had no significant correlation.

Conclusion: Our findings show that nutritional status should influence the frequencies of peripheral T cell subsets in NSCLC patients.

Published Date: 2022-06-07; Received Date: 2022-05-10