Journal of Clinical and Cellular Immunology
Open Access

Abstract

Endothelium as A Part of Septic Multiple Organ Dysfunction Syndrome (Mods)- Is Endocan an Answer?

Malgorzata Lipinska-Gediga

Sepsis is complex syndrome with endothelial barrier integrity compromise, contributing to end-organ dysfunction. Some findings have established that markers of septic endothelial activation are associated with extent of sepsis severity, organ dysfunction and mortality. Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan and endocan’s increased serum levels founded in patients with sepsis were of prognostic value.