Clinical & Experimental Cardiology
Open Access

Abstract

Fibroblast Growth Factor-23: A Possible Cause of Pulmonary Hypertension and Left Ventricle Hypertrophy in Hemodialysis Patients

Noussa Mahmoud EL-Adawy Amal Kamal Helmy, Tamer Taha Ismail*, Abd El Rahman Sayed Tawfik, Hesham Kamal Habeeb Keryakos and Mostafa Ahmed El Sayed Abu Ela

Assessment of blood level of fibroblast growth factor-23 (FGF-23) levels was done in forty patients with end-stage kidney disease (ESRD). We found that there were statistically significant positive correlations between FGF-23 and LVH, Phosphorus and Parathormone hormone. Statistically significant negative correlations were found between FGF-23 and corrected Calcium) and 25 (OH) vitamin D, but there was no significant correlation between FGF-23 and pulmonary artery systolic pressure. For prediction of FGF-23 Levels stepwise multiple linear regression analysis was done and revealed that the most 4 predictable values of FGF-23 are intact Parathormone hormone, corrected calcium, 25 (OH) vitamin D and SBP respectively. There were positive correlations between FGF-23 with LV mass and LV mass index. Statistically significant negative correlations were found between FGF-23 and LVIDs. A multiple discriminant functional analysis for prediction of LVH revealed that age, FGF-23, and Vitamin D are the most predictable variables. Hemodialysis patients with LVH had higher FGF-23 levels raising the possibility that FGF-23 may predict LVH.