Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Hepatoprotective and Antioxidative Effects of Terminalia Arjuna against Cadmium Provoked Toxicity in Albino Rats (Ratus Norvigicus)

Muhammad Tahir Haidry and Arif Malik

The extract of bark of Terminalia arjuna was investigated for its hepatoprotective and antioxidative effects
on cadmium provoked toxicity. It was found that cadmium (Cd) significantly (P<0.05) elevated the serum levels of following biomarkers alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase ALP, and malondialdehyde (MDA) simultaneously, it lowered the protein and depleted the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) upon administration of cadmium chloride (5 mg/kg) to albino rats. Study results indicated that the treatment of these rats with extracts of Terminalia arjuna (200 mg/kg) significantly reversed the effects of cadmium and proved that it has hepatoprotective, and antioxidative potential. The results also suggested that the phytochemicals present in the extract of bark of T. arjuna have potential therapeutic value.