Journal of Clinical Toxicology
Open Access

Abstract

High Rate of Increased Level of Plasma Angiotensin II and its Gender Difference in Covid-19: An Analysis of 55 Hospitalized Patients with Covid-19 in a Single Hospital, Wuhan, China

Na Liu, Yan Hong, Ren-Gui Chen, Heng-Mei Zhu

Aim: 2019 Novel coronavirus disease (COVID-19) is turning into a pandemic globally lately. There were few reports illustrated the circulating levels of Angiotensin II (AngII) in COVID-19. This study aimed to demonstrate the circulating levels of AngII in COVID-19 and how it correlated to the disease.

Methods and results: We enrolled 55 patients with COVID-19 admitted to Renmin Hospital of Wuhan University from January 21st to February 21st, 2020. Demographic data were collected upon admission. COVID-19 nuclear acid, plasma AngII, Renin and aldosterone in the lying position without sodium restriction, and other laboratory indicators were together measured by the laboratory department of our hospital. Of the 55 patients with COVID-19, 34(61.8%) had an increased level of AngII. A high level of AngII was identified in male patients and in critically ill patients. The level of blood lymphocyte, PCT, ALT, and AST were remarkably severe with patients of normal level of AngII (p<0.05). CD4/CD8 cells ratio was significantly higher in patients of normal level of AngII (p<0.05). The results of binary logistic regression analysis showed that the severity of COVID-19 (OR=4.123) and CD4/CD8 ratio(OR=4.050) were the co-directional impact factor while female(OR=0.146) was inverse impact factor of elevated AngII level.

Conclusion: High rate of increased level of AngII and its gender differences were detected in COVID-19 patients. Elevated AngII level were correlated with the severity of COVID-19 and CD4/CD8 ratio.

Published Date: 2021-03-23; Received Date: 2021-03-02