Mycobacterial Diseases
Open Access

Abstract

Inbred Mouse Strain Susceptibility to Tuberculosis Infection Vary with Phenotype, the Dose of Infection, Obesity and Composition of the Intestinal Microbiome

Svetlana I. Kayukova*, Andrew E. Donnikov, Irina V Bocharova and Boris V Nikonenko

In this work, we conducted comparative studies of inbred mice with different sensitivity to tuberculosis infection, I/St susceptible, C57BL/6 resistant. Two other strains C3H.JK (H2j), C3H/HeDiSn (H2k) began to grow fat by 4-5 months of age and changed their susceptibility depending on the dose of infection. Also, they were made obese or not in dependence on the dose of infection.

Published Date: 2021-02-25; Received Date: 2020-10-28