Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Inhibition of Tumors in Mice Models by a Synthetic Ceramide-analog AD2725

Qin JD, Weiss L, Zeira M, Yekhtin Z, Slavin S, Gatt S and Dagan A

A synthetic analog of ceramide (AD2725) elevated ceramide levels in MDA-MB-435 breast cancer cells inducing apoptosis and resulted in cell death. In animal studies, using a model of xenograft breast cancer cells in nude mice, treatment with AD2725 resulted in a significant reduction of the tumor volume and weight, and significantly prolonged survival of the treated mice. The analog also significantly elevated INF gamma and IL-12 cytokine levels and reduced the level of IL-10 in the plasma. These data indicate that use of suitable synthetic analogs that most probably elevate the ceramide levels may have beneficial anti-cancer therapeutic effects.