Journal of Antivirals & Antiretrovirals
Open Access

Abstract

Lectins: Magic Bullet towards HIV Gp120

Sindhura BR, Vishwanath Reddy H, Shashikala R Inamdar and Bale M Swamy

The AIDS epidemic, in spite of considerable efforts is continuous to spread at formidable rate worldwide with an estimated 34 million people being infected with HIV at the end of 2010. Drug discovery towards AIDS is a desperation area of research because of the down beating results of number of painstaking attempts. The key step in the disease progression is viral binding to the host T lymphocytes and entry. The gp120 and gp41 glycoproteins, derived from gp160 forms a complex that mediates the receptor and co receptor binding, subsequent membrane fusion events will permits viral entry.