Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Yenumala Vamshidhar Reddy*, Thogaru Thanish Varma and Varikuppala Anand
Spinacia oleracea is a very famous medicinal plant that bears a lot of biological activities. The high pressure in the pulmonary arteries, which is a dangerous unhealthy condition leading to heart failure and finally death, is called Pulmonary Arterial Hypertension (PAH). Hence, in the current study, there was an attempt to probe into possible active constituents of spinach with the use of network pharmacology and molecular docking in the treatment of PAH. The results identified the common targets between spinach constituents and PAH-related proteins, including hub targets such as Epidermal Growth Factor Receptor (EGFR), Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Sarcoma Proto-Oncogene (SRC) and Matrix Metalloproteinase 9 (MMP9). Pathway analysis revealed association with lipid metabolism, atherosclerosis and the Interleukin 17 (IL-17) signaling pathway. Molecular docking showed strong binding affinity between patuletin, spinacetin and the PAH-associated targets. These results have generated insight into the molecular mechanism underlying possible PAH therapies by spinach constituents.
Published Date: 2024-09-16; Received Date: 2024-08-16