Angiology: Open Access
Open Access

Abstract

Neuromuscular Electrical Stimulation for the Prevention of Deep Vein Thrombosis in Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yubo Li, Lixiang Ye, Zhaozhao Xu and huxiang Zhang*

Objective: Systematic evaluation of the effect of neuromuscular electrical stimulation in the prevention of deep vein thrombosis in patients, providing evidence-based medicine for clinical prevention of venous thrombosis.

Methods: A computerized search of PubMed, The Cochrane Library, Web of Science, and Embase was performed to collect published literature on the prevention of the development of Deep Vein Thrombosis (DVT) in patients with Neuromuscular Electrical Stimulation (NMES), with a timeframe of from the time of library construction to August 2024. Literature screening, data extraction, and quality assessment were performed independently by two investigators according to the inclusion and exclusion criteria, and then Meta-analysis was performed using RevMan 5.4 software.

Results: A total of 11 papers with 1040 study subjects were included. Meta-analysis showed that NMES could reduce the incidence of DVT (Risk Ratio (RR)=0.55, 95% Confident Interval (CI): (0.43, 0.70), p<0.00001), accelerate venous blood flow in the lower extremities Mean Difference (MD=6.27, 95% CI (2.64, 9.91), p=0.0007), however, there is insufficient evidence of improvement in D-dimer (DD) levels.

Conclusion: Neuromuscular electrical stimulation can prevent DVT in patients, but the quality level of the literature is not high, and high quality clinical studies are still needed to further validate and analyze its efficacy.

Published Date: 2024-12-26; Received Date: 2024-11-25