Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Ju Zhou, Jin Tao, Xian-Min Yu*, Xinghong Jiang
We have recently identified that the depression of MicroRNA (miRNA)-547-5p, which can be induced by a Chronic Constriction Nerve Injury (CCI), is an upstream event causing the enhancement of interleukin-33 (IL-33)/ Suppressor Tumorigenicity 2 (ST2) signaling and leading to pain hypersensitivity in rats. Moreover, the application of Bone Marrow Stromal Cells (BMSCs) reduces CCI-induced pain hypersensitivity by blocking the depression of miRNA-547-5p or its downstream molecules IL-33 and ST2. The roles of the miRNA-547-5p/IL-33/ST2 signaling pathway in the genesis of neuropathic pain and the analgesic effects of treatment with BMSCs are further discussed in this mini-review.
Published Date: 2021-10-15; Received Date: 2021-09-24