Angiology: Open Access
Open Access

Abstract

Non-Invasive Measurement of Arterial Stiffness Using the Analysis of Oscillometric Waveform during Cuff-Inflation

Kazuhiro Ide, Tomoya Kusakabe, Atsuhiro Shimakura and Masanobu Takata

Background We developed the new method which is measured arterial stiffness simultaneously with blood pressure by oscillometry during cuff inflation, and evaluated usefulness of the index as a marker of cardiovascular disease.

Methods The cuff pressure pulse waves during linear cuff inflation were extracted by blood pressure measurement device in 97 outpatients with hypertension. The paired values of the cumulatively added cuff oscillation amplitudes and the corresponding cuff pressures are stored in the device during the measurement. Each of the cumulative addition value was exchanged to the ratio of total addition, and the cuff pressures, P0 and P1, corresponding to the ratios, R0 and R1, respectively, were used for calculation of the Cuff-Oscillometric Stiffness Parameter (CSP) which was defined as ln (P1/P0) / (R1/R0-1). Furthermore, we calculated the Modified Cuff-Oscillometric Stiffness Parameter (MCSP) using CSP, age, height and weight. We also measured Cardio-Ankle Vascular Stiffness Index (CAVI), the carotid Intima-Media Thickness (IMT), blood chemistry, and Framingham Risk Score (FRS) for coronary heart disease.

Results CSP was significantly correlated with CAVI(r= 0.608, p <0.0001). There were significant correlated with IMT, FRS. MCSP was closely correlated with CAVI(r= 0.803, p <0.0001). In addition, CSP, MCSP, and CAVI were associated with blood components as markers of diabetes.

Conclusions These results suggest that our new method is useful for the screening arteriosclerosis-related disease, and helpful for health care management in home because of easy to use, low cost, and short time measuring.