Journal of Clinical Trials
Open Access

Abstract

Non-Invasive Strategies for Nose-to-Brain Drug Delivery

Novak V*, Trevino JA, Quispe RC and Khan F

Intranasal drug administration is a promising method for delivering drugs directly to the brain. Animal studies have described pathways and potential brain targets, but nose-to-brain delivery and treatment efficacy in humans remains debated. We describe the proposed pathways and barriers for nose-to-brain drug delivery in humans, drug properties that influence central nervous system delivery, clinically tested methods to enhance absorption, and the devices used in clinical trials. This review compiles the available evidence for nose-to-brain drug delivery in humans and summarizes the factors involved in nose-to-brain drug delivery.

Published Date: 2020-12-10; Received Date: 2020-10-27