Journal of Developing Drugs
Open Access

Abstract

Novel Insights in G-Protein-Coupled Receptor of Signal Transduction Relevant to Recent Developments in Drug Action

Jessie Evan*

Many discoveries in the biological sciences and especially at the molecular and genetic level over the last two decades in particular have had a profound effect on our knowledge and understanding of drug action and have helped to develop new drugs and therapeutic strategies. Furthermore, many exciting new drugs that work through the novel pharmacological mechanisms are expected to be of clinical use in the very distant future. In this context, with a specific reference to the pharmacology of G-protein-coupled receptors, these concepts are illustrated and their relevance is illustrated by examples of drugs commonly used in the clinical setting. In addition, the mechanisms by which receptor signaling and ultimately drug response are regulated by receptor promiscuity, receptor trafficking, and Regulators of G-protein Signaling (RGSs) are well tuned from theory to the proposed therapeutic implications.

Published Date: 2022-12-14; Received Date: 2022-11-14