Pancreatic Disorders & Therapy
Open Access

Abstract

Pancreatic Serous Cystadenocarcinoma: Are You Really So Malignant?

Filippo Antonini, Giampiero Macarri and Francesco Ferrara

In 2010 the World Health Organization described pancreatic serous cystadenocarcinoma (SCAC) as a serous cystadenoma that presents metastases or invasion of adjacent organs. Although a handful of cases have been described in literature, this entity shows some discrepancies. The dilemma can arise starting on the concept of “metastases” and “invasion”: any of reported SCAC shows clear histopathological features of malignancy. Moreover no patient deceased for reasons specifically related to SCAC, even those with metastatic disease. For these reasons, several cases defined as SCACs are not convincing.