Endocrinology & Metabolic Syndrome
Open Access

Abstract

Pharmacogenetics of Oral Antidiabetic Drugs: Potential Clinical Application

Ji-Ye Yin, Yu Guo, Qiong Huang, Hong Sun, Hong-Hao Zhou and Zhao-Qian Liu

Oral antidiabetic drugs (OADs) are widely used to treat type 2 diabetes mellitus (T2DM). However, inherited difference is one of the major issues that affect OADs therapeutic efficacy. In the present paper, we performed a critical review on recent advances in genetic polymorphisms that influence OADs therapeutic efficacy and metabolism. Sulfonylureas (SUs), Meglitinides, Metformin and Thiazolidinediones (TZDs) will be discussed.