Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis

Wonhwa Leeand Jong-Sup Bae

High Mobility Group Box 1 (HMGB1) is highly conserved through evolution, and has 99% identity among all mammals. Out of its 215 amino acids, only two residues are substituted in the rodent and human versions. HMGB1 was originally described as a nuclear protein that binds DNA, and functions as a co-factor that is required for transcriptional regulation and gene expression.