Journal of Drug Metabolism & Toxicology
Open Access

Abstract

Prevention of Cadmium Toxicity by Ceftriaxone plus Sulbactam with VRP1034 in Rats

Vivek Kumar Dwivedi, Anuj Bhatanagar and Manu Chaudhary

The aim of this study was to determine the prevention of cadmium toxicity by ceftriaxone plus sulbactam with VRP1034 drug on hematological, biochemical, lipid per-oxidation, antioxidant enzymatic activities and Cd, Zn and Fe levels in the blood and tissues of cadmium exposed rats. Twenty four male rats were divided into three groups of eight rats each. Control group received distilled water where as group II received CdCl2 (1.5 mg/4 ml body weight) through gastric gavages for 21 days. Group III was received CdCl2 plus treated with ceftriaxone plus sulbactam with VRP1034 for 21 days. These parameters were measured in plasma and tissues (brain, liver and kidney) of all groups. Our findings showed that a significantly decreased cadmium (p<0.001), malonaldialdehyde (p<0.001), MPO levels along with significant increased hemoglobin (p<0.01), red blood cell (p<0.05), hematocript(p<0.05) levels and all antioxidant enzymatic activities in plasma and tissues of ceftriaxone plus sulbactam with VRP1034 treated group as compared to cadmium exposed group. δ -aminolevulinic acid dehydratase activity was significantly (p<0.001) increased in the blood of ceftriaxone plus sulbactam with VRP1034 treated group as compared to cadmium exposed group. The levels of hepatic and renal parameters were significantly (p<0.001) decreased in ceftriaxone plus sulbactam with VRP1034 treated group as compared to cadmium exposed group. So these finding concluded that ceftriaxone plus sulbactam with VRP1034 act as potent free radical scavenger and metal chelating properties that reduces free radical mediated tissue injury and prevent hepatic and renal organs dysfunction during cadmium intoxication.