Journal of Clinical Toxicology
Open Access

Abstract

Protective and Anti-oxidant Activity of the Euryops Arabicus against Paracetamol Induced Hepatorenal Toxicity in Rats

Essam Mahmoud Hafez, Milad Gad Paulis, Mostafa Abotaleb Ahmed, Marian NagyFathy, Ahmed Abdel-Lateff and Mardi M. Algandaby

Paracetamol overdose is a predominant cause of hepatorenal toxicity in both humans and experimental animals. The extract of Euryops arabicus was evaluated for its protective and anti-oxidant effect against paracetamol-induced hepatic and renal injuriesin rats. The extract of Euryops arabicus was administered at100 mg/kg and 200 mg/kg followed by paracetamol at 1g/kg for seven days. The animals were sacrificed after 24 hrs of paracetamol challenge .Indices of liver such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), serum albumin (SA) and renal indices blood urea (BU) and serum creatinine (SC) were measured. Liver and kidney homogenates were analyzed for oxidative stress biomarkers namely Thiobarbituric acid reactive substances TBARS. Finally, histopathological examinations of both previous organs were examined. The significantly disturbed liver and kidney functions by paracetamol toxicity were restored to almost normal values by administration of Euryops arabicus. Also, the elevated TBARS in groups received paracetamol alone decreased in groups given paracetamol and Euryops arabicus. Histological effect of paracetamol on liver and kidney was also markedly abolished by co-administration of Euryops arabicus. These results suggest that Euryops arabicus may protectfrom paracetamol-induced liver and kidney toxicity.