Journal of Molecular Imaging & Dynamics
Open Access

Abstract

Radiochemical and Biological Evaluation of ^99mTc-Labeling of Phthalic Acid Using ^99mTc-Tricabonyl and ^99mTc-Sn (II) As a Model for Potential Hazards Imaging

Sanad MH, Saad MM, Fouzy ASM, Marzook F, Ibrahim IT

In this study, 99mTc- phthalic acid (PA) firstly, was prepared with a high radiochemical yield up to 98% that confirmed with different chromatographic techniques by using 2 mg phthalic acid, 50 ?g SnCl2·2H2O as a reducing agent, in solution of pH 7 at room temperature for 30 min. Secondly, 99mTc-tricarbonyl phthalic acid was prepared under 30 min heating at 100°C. Bio distribution studies were carried out in Albino Swiss mice in which 99mTc-PA and 99mTc-tricarbonyl PA were concentrated in kidneys and intestine. This work aims to evaluation of labeled PA as a model for Potential Hazards imaging in vitro and in vivo toxicity in Albino Swiss mice.