Translational Medicine
Open Access

Abstract

Reprogrammed Cellular Metabolism and O -GlcNAc Modification in Cancer

Suresh Mishra

The capability to reprogram cellular metabolism in order to most effectively support proliferating cancer cells has been emerging as a hallmark of cancer. As a result, there has been a resurgence of interest in the field of tumour metabolism. Additionally, this reappearance in interest may partly be attributed to the tremendous capability of the recent technological advancement to explore the relationship between cellular metabolism and cancer to an extent which was not possible before. The most fundamental trait of cancer cells involves their ability to sustain cell proliferation in an uncontrolled manner. Uncontrolled cell growth also require intracellular metabolic adjustment to meet the continual demand of energy and macromolecules by the proliferating cells [1]. This necessity is well known to be served by increased glucose uptake and anaerobic glycolysis by cancer cells, also known as the Warburg effect [2].