Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Abstract

Review: The Influence Of Endometrial Thickness On IVF Outcomes

Emma Boys, Michael Chapman

Background: Assisted Reproductive Technology (ART) including In-Vitro Fertilisation (IVF) has led to improved outcomes for sub fertile couples and individuals. Endometrial thickness, a sensitive and reproducible marker of endometrial receptivity has been linked to success rates in IVF. Consequently, the purpose of this study was to review this association.

Methods: A literature search using the Cochrane library, EMBASE and MEDLINE was performed for eligible articles (n=11).

Results: Seven studies suggested that endometrial thickness had no impact on pregnancy rates. Four studies suggested that increased endometrial thickness had a positive effect on pregnancy rates. Two studies concluded that extreme endometrial thicknesses were negatively associated with pregnancy rates.

Conclusions: Existing prospective and retrospective studies suggest that extreme endometrial thicknesses may have a negative impact on IVF pregnancy rates. However, no definitive conclusions for clinical practice have been reached in terms of appropriate endometrial thickness thresholds.