Journal of Clinical Toxicology
Open Access

Abstract

Severe Toxic Myocarditis Following Sodium Valproate Poisoning: A Management Hurdle

Aruna Shantha DW*, Kulasinghe A and Hettiarachchi NM

Sodium valproate is a commonly reported medication with self-inflicted overdose causing morbidity and mortality with severe toxicity. Myocarditis is not a commonly reported complication in valproate poisoning. There is no consensus guideline for the management up to date. We are reporting a case of severe myocarditis with refractory hypotension which was successfully treated with High-dose Insulin Euglycemic Therapy (HIET). We highlight the importance of anticipating toxic myocarditis as a complication of valproic acid poisoning and the possibility of restoration of “metabolic hunger” by HIET which could have been caused by the depletion of myocytic L-carnitine activity.

Published Date: 2024-05-23; Received Date: 2024-04-22