Biochemistry & Pharmacology: Open Access
Open Access

Abstract

SMAC Mimetics: Promising Therapeutic Agents in Cancer and other Diseases

Laurence Dubrez

Smac mimetics are a very promising new class of anticancer agents demonstrating an acceptable safety profile and efficacy in some preclinical models of cancers when used as a single agent or in combination with conventional or nonconventional therapies. Future preclinical and clinical trials could enlarge their spectral of action in inflammatory, fibrotic and infectious diseases.