Journal of Clinical and Cellular Immunology
Open Access

Abstract

Spermidine Related Autophagy Flux Deficiency is a Novel Pathogenesis of Aplastic Anemia

Jian Li, Qiyuan Li*, Guo Fu, Qing Li, Zunnan Huang, Yongjian Su, Shunqing Wang, Ruiqing Zhou*, Kefeng Wu*, Qinwei Chen, Jinqi Huang*, Yuchan You, Changmei Lin, Jie Long, Liang Liang, Sijie Wang, Chen Yang, Juan Xia and Yuming Zhang

Aplastic Anemia (AA) is a hematopoietic failure symptom of the bone marrow that can be caused by a variety of factors such as T-cell mediated immune attack, genetic-related somatic mutations, cytogenetic abnormalities, and defective telomerase functions. Recently, Single-cell RNA-sequencing (scRNA-seq) analysis of bone marrow-derived Hematopoietic Stem and Progenitor Cells (HSPCs) from AA patients also revealed the involvement of selective lineage disruption, altered alternative splicing, and polyadenylation in AA pathogenesis . However, these new mechanisms did not provide any new therapeutic approaches for AA, as novel therapies are urgently needed for patients who received no durable benefit from immunosuppressive therapy combined with the Thrombopoietin Receptor (TpoR) activator and patients who underwent allogeneic hematopoietic stem cell transplantation. Therefore, further research is warranted for a deeper understanding of AA and better treatment of this disease.

Published Date: 2022-07-22; Received Date: 2022-06-21