Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Abstract

Study of the Effect of Age, Body Mass Index, Gestation, Parity, and Fruit and Vegetable Consumption on Plasma Antioxidant Activity of Healthy Women by Scavenging the Radical ABTS?+

N’negue ép. Mezui-Mbeng M-A*, Makoyo Komba O, Bang Ntamack J A, Nkolo Ovouele J-C, Lendoye E and Edou Engonga P

Introduction: Aging is a slow and progressive process different from disease, whose main cause is the presence of free radicals and oxidative attacks on mitochondrial DNA in the body. The frequency of mitochondrial DNA deletions would increase exponentially from the age of 50 years to reach considerable levels in older people Objectives: To measure the antioxidant activity of the plasma of healthy women without chronic pathology whose etiology would be related to the oxidative stress, and whose age is lower or equal to 50 years, by scavenging of the free radical ABTS•+.The aim of the study is to observe the evolution of the antiradical capacity of the blood with age, up to 50 years.

Results: The mean antiradical activity of women of ages>40 years was 2.2% higher than that of women of age’s ≤ 40 years. The antiradical activity of overweight women with a Body Mass Index (BMI) greater than 25 and a mean age of 42.16 ± 7.78 years was more or less equivalent to that of normal-bodied women with a BMI less than 25 having a mean age of 36.25 ± 8.95 years. The mean antiradical activity of women with less than 3 gestation and a mean age of 32.25 ± 7.13% is little different from that of women with gestation of 3 or more with a mean age of 44.83 ± 4.35%. The mean antiradical activity of women with parities less than 3 and a mean age of 35 ± 7.32 years is equivalent to that of women with parities greater than or equal to 3 with a mean age of 47.83 ± 2.16%. The antiradical activity of the plasma of women consuming 2 to 3 fruits and vegetables per day with a mean age of 43.6 ± 4.39 is about 3.5% higher than those of women consuming only 1 fruit and vegetable/day with a mean age of 36 ± 10.07.

Conclusion: The evaluation of the total antioxidant capacity of women's blood by radical scavenging shows that a slight oxidative stress is already progressively established in the blood plasma of women up to the age of 50. The consumption of fruits and vegetables enriches the organism in antioxidant compounds. A gestité and parity superior or equal to 3 slow down the appearance of oxidative stress.

Published Date: 2022-02-07; Received Date: 2022-01-06