Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Abstract

Successful Pregnancy in Recurrent Thin Endometrium with New Uses for an Old Drug

Xin Chen and Shi-ling Chen

Objective: To analyze whether the use of tamoxifen is a feasible option in repeated unresponsive thin
endometrium (<6 mm) with standard treatment options.
Methods: Three consecutive women undergoing Frozen Embryo Transfer (FET) who, after standard endometrial
preparation, still showed thin endometrium (<6 mm). They were all given with tamoxifen treatment.
Results: Successful endometrial expansion to at least 7.7 mm after tamoxifen treatment in three patients
previously with thin endometrium in abandoned IVF cycles, natural cycles and extended estrogen treatment cycles with aspirin. All the three patients performed embryo-transfer, and they all conceived. One singleton stopped growing on gestational week 8. Two deliveries produced three healthy children.
Conclusion: In patients of recurrent thin endometrium, regardless of whether abandoned IVF cycles, natural cycles or extended estrogen treatment cycles with aspirin, tamoxifen treatment may be a successful alternative approach.