Pharmaceutical Analytical Chemistry: Open Access
Open Access

Abstract

The Comparison between HBV Transgenic Mice and Normal Mice after Being Injected Concanavalin A (Con A)

Yi Cheng, Guangze Liu, Mao Mu, Song You, Xiangping Kong and Caifang Zhuang

HBV transgenic mice are used as chronic hepatitis B models for research, but they cannot be infected by HBV to have the hepatitis B as the same as human. In the research, we explored the differences between HBV transgenic mice and normal mice who are injected the concanavalin, A which can injure the livers of the mice. We found some data to show the differences of them after the injection, such as weight, pictures of the liver tissue, alanine transaminase (ALT) and aspartate transaminase (AST) in the blood. The pro-inflammatory cytokines (IL-6, IFN-γ and TNF-α) and T cells (CD4+ cells and CD8+ cells) also showed the livers of HBV transgenic mice were more vulnerable to be hurt than normal mice.