Journal of Leukemia
Open Access

Abstract

The IL8 (CXCL8)/CXCR1/2 Axis: A Potential Target for the Treatment of Myelofibrosis

Ronald Hoffman* and Min Lu

The Myelofibrosis (MF) Inflammatory milieu contributes to the development of patient specific systemic symptoms, alterations in tissue specific micro-environments and immune dysfunction which sustain the survival advantage of malignant hematopoietic stem/progenitor cells. Interleukin-8 (IL8) is a chemokine that plays a pivotal role in MF disease progression by not only directly affected malignant hematopoiesis but also the tumor microenvironment and immunity. We presented a series of both in-vitro and in-vivo studies which docum1ent the impact of IL8/CXCR1/2 signaling on MF disease progression and identify this pathway as a therapeutic target for MF patients.

Published Date: 2023-06-07; Received Date: 2023-05-06