Journal of Sleep Disorders & Therapy
Open Access

Abstract

The Promising Effect of Automatic Positive Airway Pressure in Heart Failure Patients Suffering from Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Mohammad Nourabi, Mehdi Geravandi, Sara Zand, Sina Dolatshahi, Hossein Hosseinifard, Moein Geravandi and Zahra Hooshanginezhad*

Purpose: There is a link between Heart Failure (HF) and Sleep Disordered Breathing (SDB). Obstructive Sleep Apnea (OSA) patterns affect the Left Ventricular Ejection Fraction (LVEF) in HF. The current study aimed to evaluate the effect of Automated Positive Airway Pressure (APAP) in HF patients with OSA.

Methods: A systematic search in databases PubMed, Medline, Cochrane Library, Scopus, and Web of Science from January 1980 to January 2023 was performed to find the related articles. Then, the Cochrane risk of bias tool was used to assess the risk of bias. Finally, the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) were employed to judge the robustness of the evidence. In order to combine the results, Random Effect (RE) or Fixed Effect (FE) models were used.

Results: Three studies were eligible based on the inclusion criteria. The patients in the intervention and control groups were 47 and 55, respectively. The mean age of patients in the intervention and control groups was 66.33 and 66.2 years, respectively. The meta-analysis results showed that the mean of integrated changes for LVEF, 6-MWT, and peak VO₂ was (MD=2.48, 95% CI: 0.10 to 4.85, p-value=0.04), (MD=13.82, 95% CI: -77.98 to 35.63, p-value= 0.214 and (MD=1.03, 95% CI: -0.125 to 2.18, p-value=0.081), respectively.

Conclusion: In patients with HF and OSA, Automatic PAP (APAP) can improve the amount of LVEF. In addition, APAP therapy also increases 6-MWT and peak VO₂.

Published Date: 2024-01-03; Received Date: 2023-05-26