Journal of Clinical and Cellular Immunology
Open Access

Abstract

TNF-α, IL-1β and IL-10 Gene Polymorphisms and their Association to Toxoplasmosis of Aborted Women in Sulaimania City

Latif Omer Mohammed

Toxoplasmosis is the disease that is caused by an obligatory intracellular parasite Toxoplasma gondii. Cytokines have a function in its pathogenesis. The single nucleotide polymorphisms (SNPs) of every cytokine have been reported to have functioned in etiologic. So the target of the introduced study, is to examined the relationship between the SNPs of mentioned interleukins and toxoplasmosis of 50 toxoplasmosis – aborted women were attend to maternity hospital in Sulaimania city through the period Jan 2017 – March 2017 to ending their pregnancy and 40 healthful women (University staff and wellbeing staff) as control. SNPs were detected by PCRSSP (Polymerase chain reaction-sequence specific priming) technique. Latex agglutination test and Enzyme linked Immunosorbent assay for IgG and IgM concluded that 34% of samples were confirmed for IgG and IgM anti-Toxoplasma antibodies.

This study observed that there no significant positive or negative relationship between the SNPs of mentioned interleukins and toxoplasmosis in the cases of aborted women in Sulaimania city/north of Iraq.