Dr. Sabih Ahmed
Introduction: Acute coronary syndrome is defined as "cardiac pain that does not settle with rest or nitrates". Symptoms include chest heaviness, diaphoresis, sweating, etc. Plaste-rich plasma is the RBC, WBC and platelets-rich portion of the blood and is produced by adding anticoagulant and centrifuging the whole blood. It has various properties, which include anti-inflammatory, anti-scarring, blood clotting, immune response, etc. In this study, the above-mentioned anti-inflammatory and anti-scarring properties of damaged cardiac tissue were studied and the response was measured in terms of wall kinesis and Ejection Fraction. Methods: The study was conducted in Jinnah hospital, Lahore from 5th May 2022 to 4th October 2022. The study was a cohort study and fifty patients were included. All patients had a sedentary lifestyle rest of the physical and mental condition was regular. It was a triple-blind study and patients were divided into the control and placebo group. All patients had the acute coronary syndrome and 200 ml platelet-rich plasma was infused through the same angioplasty catheter after angioplasty. Paired t-test was used to measure values of kinesis and ejection fraction by echocardiography at six weeks, one and half months and six months with a statistical significance of <0.05. Results: 8.28% vs. 16.08% was the difference in the akinesis area, while 52.6% vs. 45% was the difference in ejection fraction, with the latter being the value of the placebo group. It is evident from the study that the use of platelet-rich plasma after angioplasty had a positive effect on cardiac muscles. The use of platelet-rich plasma has properties that are beneficial to the cardiac muscles, which, resulted in better recovery of revascularized area.
Published Date: 2025-01-23;