Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Áurea Casal
Spain
Review Article
Insights into the Transcriptional Regulation of the Unrearranged and Rearranged Tcra and Tcrd Genes
Author(s): Cristina Hernández-Munain, Áurea Casal, Belén Juanes, Jennifer López-Ros, and Alonso Rodríguez-CaparrósCristina Hernández-Munain, Áurea Casal, Belén Juanes, Jennifer López-Ros, and Alonso Rodríguez-Caparrós
The combined T-cell receptor α and δ locus, Tcra/Tcrd, encodes the TCRα and TCRδ chains of the αβ or γδ T-cell receptors (TCRαβ and TCRγδ), respectively, which define the two distinct T-cell lineages, αβ and γδ T lymphocytes. Like other antigen receptor loci, this locus must recombine its variable (V), diversity (D), and joining (J) gene segments to generate a diverse range of TCR that allow vertebrates to respond to an unlimited number of antigens. The Tcra/Tcrd germline transcription and subsequent V(D)J gene segment rearrangements are strictly regulated by two distant transcriptional enhancers, Eα and Eδ, respectively, during thymocyte development. Once the Tcra locus is productively rearranged, it is assumed Eα remains active for the transcription of the rearrang.. View More»
DOI:
10.4172/2155-9899.1000415